Advanced Cardiovascular Life Support (ACLS) Practice Exam 2026 – Your Comprehensive All-in-One Guide to Exam Success!

The recommended oral dose of aspirin for patients suspected of having an acute coronary syndrome is between 160 to 325 mg. This dosage is effective for its antiplatelet properties, which play a critical role in reducing the risk of further clot formation in a patient experiencing a myocardial infarction or unstable angina.

Aspirin inhibits platelet aggregation by blocking the enzyme cyclooxygenase, which is pivotal in the formation of thromboxane A2, a substance that promotes platelet aggregation. Administering the appropriate dose promptly can help minimize the impact of the acute coronary event and can be a life-saving intervention.

In the context of the other listed dosages, lower doses such as 50 to 100 mg or 125 to 200 mg would not provide sufficient antiplatelet effect for the purpose of managing an acute coronary syndrome. The higher dose of 300 to 400 mg may also exceed the recommended threshold for initial treatment, as current guidelines suggest that 160 to 325 mg is adequate and effective for immediate use. Therefore, choosing a dose within the range of 160 to 325 mg is consistent with accepted protocols in advanced cardiovascular life support.